Original Article (English)
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Kawamura, Y., Fujimoto, Y., Kutsuna, R., Tomida, J.,
Yamamoto, K., Miyoshi-Akiyama, T., Okuno, M., Ogura, Y., Matsuoka, M., Kawaguchi, T., Tsutsuki, H., Sawa, T. Helicobacter
kumamotonesis sp. nov., isolated from human clinical specimens. Int. J. Syst. Evol. Microbiol. 2023 Mar; 73(3). doi: 10.1099/ijsem.0.005732.
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Harada, A., Xu, W., Ono, K., Tsutsuki, H., Yahiro, K., Sawa, T., Niidome, T. Modification of silver nanoparticles with cell-binding subunit of bacterial toxin and their antimicrobial activity against intracellular
bacteria. ACS Applied Bio Mater., 2023 Mar 27. doi: 10.1021/acsabm.3c00019. Online ahead of print.
Review (Japanese)
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澤 智裕. 環境カルボニルストレスと生体応答. Medical Science Digest, 49(1): 21-24, 2023.
Original Article (English)
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Islam, W., Tsutsuki, H., Ono, K., Harada, A., Shinozaki, K., Niidome, T., Fang, J., Sawa, T., Structural Determination of the Nanocomplex of Borate with Styrene–Maleic
Acid Copolymer-Conjugated Glucosamine Used as a Multifunctional Anticancer Drug. ACS Appl. Bio Mater. 2022, December
8, https://doi.org/10.1021/acsabm.2c00883.
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Monde, K., Satou, Y., Goto, M., Uchiyama, Y., Ito, J., Kaitsuka, T., Terasawa, H., Monde, N., Yamaga, S., Matsusako, T., Wei, F-Y., Inoue, I.,
Tomizawa, K., Ono, A., Era, T., Sawa, T., Maeda, Y., Movements of Ancient Human Endogenous Retroviruses Detected in SOX2-Expressing Cells. J. Viol. 2022 May
11;96(9):e0035622. DOI: https://doi.org/10.1128/jvi.00356-22.
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Yamane, T., Kanamori, Y., Sawayama, H., Yano, H., Nita, A., Ohta, Y., Hinokuma, H., Maeda, A., Iwai, A., Matsumoto, T., Shimoda, M.,1 Niimura, M., Usuki, S.,
Yasuda-Yoshihara, N., Niwa, M., Baba, Y., Ishimoto, T., Komohara, Y., Sawa, T., Hirayama, T., Baba, H., Moroishi1, T., Iron accelerates Fusobacterium nucleatum–induced CCL8 expression in macrophages and is associated with colorectal cancer
progression. JCI Insight. 2022;7(21):e156802.https://doi.org/10.1172/jci.insight.156802.
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Tsutsuki, H., Zhang, T., Yahiro, K., Toyomoto, T., Sawa, T., Non-canonical inflammasome activation analysis in a mouse model of Citrobacter rodentium infection. STAR Protocols 2022, Vol. 3, Issue
4, 101741; https://doi.org/10.1016/j.xpro.2022.101741.
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Harada, A., Tsutsuki, H., Zhang, T., Yahiro, K., Sawa, T., Niidome, T., Controlled Delivery of an Anti-Inflammatory Toxin to Macrophages by Mutagenesis and Nanoparticle Modification. Nanomaterials 2022, 12(13),
2161; https://doi.org/10.3390/nano12132161 (registering DOI).
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Tsutsuki, H., Zhang, T., Yahiro, K., Ono, K., Fujiwara, Y.,
Iyoda, S., Wei, F.Y., Monde, K., Seto, K., Ohnishi, M., Oshiumi, H., Akaike, T., Sawa, T., Subtilase cytotoxin from Shiga-toxigenic Escherichia coli impairs the inflammasome and exacerbates
enteropathogenic bacterial infection. iScience, 2022, VOLUME 25, ISSUE 4, 104050, DOI:https://doi.org/10.1016/j.isci.2022.104050.
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Kasamatsu, S., Tsutsuki, H., Ida, T., Sawa, T., Watanabe, Y., Akaike, T., Ihara, H. Regulation of nitric oxide/reactive oxygen species redox signaling by nNOS splicing variants. Nitric Oxide, 2022 Jan 13; S1089-8603(22)00012-X. doi: 10.1016/j.niox.2022.01.004. Online ahead of print.
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Nomoto, D., Baba, Y., Liu, Y., Tsutsuki, H., Okadome, K., Harada, K., Ishimoto, T., Iwatsuki, M., Iwagami, S., Miyamoto, Y., Yoshida, N., Watanabe, M., Moroishi, T., Komohara,
Y., Sawa, T., Baba, H., Fusobacterium nucleatum promotes esophageal
squamous cell carcinoma progression via the NOD1/RIPK2/NF-κB pathway. Cancer Lett. 2022 Jan 13; S0304-3835(22)00022-2. doi: 10.1016/j.canlet.2022.01.014. Online ahead of
print.
Review (English)
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Islam, W., Niidome, T., Sawa, T., Enhanced
Permeability and Retention Effect as a Ubiquitous and Epoch-Making Phenomenon for the Selective Drug Targeting of Solid Tumors. J. Pers. Med. 2022, 12(12), 1964;
https://doi.org/10.3390/jpm12121964.
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Zhang, T., Tsutsuki, H., Li, X., Sawa, T. New insights into the regulatory roles of glutathione in NLRP3-inflammasome-mediated immune and inflammatory
responses. The Journal of Biochemistry, mvab158, https://doi.org/10.1093/jb/mvab158. Online ahead of print.
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Sawa, T., Akaike, T. Viruses: What triggers
inflammation in COVID-19? eLife 2022;11:e76231 DOI: 10.7554/eLife.76231.
Original Article (English)
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Akter, S., Migiyama, Y., Tsutsuki, H., Ono, K., Hamasaki,
C., Zhang, T., Miyao, K., Toyomoto, T., Yamamoto, K., Islam, W., Sakagami, T., Matsui, H., Yamaguchi, Y., Sawa, T. Development of potent antipseudomonal β-lactams by means of polycarboxylation of aminopenicillins.
Microbiol Immunol. 2021 Jul 12. doi: 10.1111/1348-0421.12930.
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Islam, W., Kimura, S., Islam, R., Harada, A., Ono, K., Fang, J., Niidome, T., Sawa, T., Maeda,
H. EPR-Effect Enhancers Strongly Potentiate
Tumor-Targeted Delivery of Nanomedicines to Advanced Cancers: Further Extension to Enhancement of the Therapeutic Effect. J Pers Med. 2021 Jun; 11(6): 487. doi:
10.3390/jpm11060487. PMID: 34071552
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Ono, K., Kitamura, Y., Zhang, T., Tsutsuki, H., Rahman, A., Ihara, T., Akaike, T., Sawa, T. Cysteine Hydropersulfide Inactivates β-Lactam Antibiotics with Formation of Ring-Opened Carbothioic S-Acids in
Bacteria. ACS Chem. Biol. (2021) Mar 29. doi: 10.1021/acschembio.1c00027. PMID: 33781062
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Zhang, T., Tsutsuki, H., Islam, W., Ono, K., Takeda, K., Akaike, T., Sawa, T. ATP exposure stimulates glutathione efflux as a necessary switch for NLRP3 inflammasome
activation. Redox Biol., 41:101930 (2021). doi: 10.1016/j.redox.2021.101930. PMID: 33740502
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Kamo, M., Ito, M., Toma, T.,Gotoh, H., Shimozono, R., Nakagawa, R., Koga, R., Monde, K., Tateishi, H., Misumi, S., Otsuka, M., Fujita, M. Discovery of anti-cell migration activity of an anti-HIV heterocyclic compound by
identification of its binding protein hnRNP M. Bioorganic chemistry 107:104627-104627, 2021.
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Islam, W., Matsumoto, Y., Fang, J., Harada, A., Niidome, T., Ono, K., Tsutsuki, H., Sawa, T., Imamura,
T., Sakurai, K., Fukumitsu, N., Yamamoto, H., Maeda, H. Polymer-conjugated glucosamine complexed with boric acid shows tumor-selective accumulation and
simultaneous inhibition of glycolysis. Biomaterials. 269: 120631 (2021). doi: 10.1016/j.biomaterials.2020.120631.Epub 2020 Dec 26.PMID: 3345058
Review (English)
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Sawa, T., Tanaka, T., Matsunaga, T., Ihara, H., Motohashi, H., Akaike, T. Chemical Biology of Reactive Sulfur Species: Hydrolysis-Driven Equilibrium of
polysulfides as a Determinant of Physiological Functions. Antioxid & Redox Signal. 2022 Feb;36(4-6):327-336. doi:
10.1089/ars.2021.0170. Epub 2022 Jan 4.
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Zhang, T., Tsutsuki, H., Ono, K., Akaike, T., Sawa, T. Antioxidative and anti-inflammatory actions of reactive cysteine persulfides. J. Clin. Biochem. Nutr.,
68: 5-8, 2021.
Review (Japanese)
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津々木博康, 張田力, 澤智裕. 超硫黄分子の抗炎症作用. 生化学 Vol.93 No.5, doi:10.14952/SEIKAGAKU.2021.930666
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澤 智裕. 超硫黄分子による自然炎症の制御と治療展開.実験医学 2021年8月号 Vol.39 No.13,
Original Article (English)
- Liu, Y., Baba, Y., Ishimoto, T., Tsutsuki, H., Zhang, T., Nomoto, D., Okadome, K., Yamamura, K., Harada, K., Eto, K., Hiyoshi, Y., Iwatsuki, M., Nagai, Y.,
Iwagami, S., Miyamoto, Y., Yoshida, N., Komohara, Y., Ohmuraya, M., Wang, X., Ajani, JA., Sawa, T., Baba, H. Fusobacterium nucleatum confers chemoresistance by modulating autophagy in oesophageal
squamous cell carcinoma. Br J Cancer. 124:963-974 (2020). doi: 10.1038/s41416-020-01198-5. PMID: 33299132
- Padilla, ST., Niki, T., Furushima, D., Bai, G., Chagan-Yasutan, H., Telan, EF., Tactacan-Abrenica, RJ., Maeda, Y., Solante, R., Hattori, T. Plasma Levels of a
Cleaved Form of Galectin-9 Are the Most Sensitive Biomarkers of Acquired Immune Deficiency Syndrome and Tuberculosis Coinfection. Biomolecules 10 :1495,2020
- Huang, S.-F., Othman, A., Koshkin, A., Fischer, S., Fischer, D., Zamboni, N., Ono, K., Sawa, T., Ogunshola, O.O. Astrocyte glutathione maintains endothelial
barrier stability. Redox Biol., 34: 101576, 2020.
- Maeda, Y., Takemura, T., Chikata, T., Kuwata, T., Terasawa, H., Fujimoto, R., Kuse, N., Akahoshi, T., Murakoshi, H., Van Tran, G., Zhang, Y., Pham, C.H., Pham,
A.H.Q., Monde, K., Sawa, T., Matsuoka, S., Nguyen, T.V., Nguyen, K.V., Hasebe, F., Yamashiro, T., Takiguchi, M. Existence of replication-competent minor variants with different coreceptor usage
in plasma from HIV-1-infected individuals. J. Virol., 94: e00193-20, 2020.
- Harada, A., Tsutsuki, H., Zhang, T., Lee, R., Yahiro, K., Sawa, T., Niidome, T. Preparation of biodegradable PLGA-nanoparticles used for pH-sensitive
intracellular delivery of an anti-inflammatory bacterial toxin to macrophages. Chem. Pharm. Bull., 68: 363-368, 2020.
- Tsutsuki, H., Kasamatsu, S., Kunieda, K., Ida, T., Sawa, T., Sasakawa, N., Akaike, T., Ihara, H. 8-Nitro-cGMP modulates exocytosis in adrenal chromaffin cells.
Biochem Biophys Res Commun. 2020 May 21; 526(1): 225-230. doi: 10.1016/j.bbrc.2020.03.045. Epub 2020 Mar 20.
- Tsutsuki, H., Zhang, T., Harada, A., Rahman, A., Ono, K., Yahiro, K., Niidome, T., Sawa, T. Involvement of protein disulfide isomerase in subtilase
cytotoxin-induced cell death in HeLa cells. Biochem Biophys Res Commun. 2020 May 14; 525(4): 1068-1073. doi: 10.1016/j.bbrc.2020.03.008. Epub 2020 Mar 14.
Review (English)
- Tsutsuki, H., Ogura, K., Moss, J., Yahiro, K. Host response to the subtilase cytotoxin produced by locus of enterocyte effacement-negative Shiga-toxigenic
Escherichia coli. Microbiol Immunol. 64:657-665 (2020). doi: 10.1111/1348-0421.12841. Epub 2020 Sep 29. PMID: 32902863
- Sawa, T., Motohashi, H., Ihara, H., Akaike,T. Enzymatic Regulation and Biological Functions of Reactive Cysteine Persulfides and Polysulfides. Biomolecules.
10(9): 1245, 2020. 2020 Aug 27.doi: 10.3390/biom10091245.
Review (Japanese)
- 澤 智裕. 活性イオウによるToll様受容体シグナルの機能制御.実験医学(増刊) 38 (10): 167-172, 2020